※ Other family introduction

    RKIP contains a novel phospho-amino acid binding domain. Substitutions in the ligand binding site of RKIP compromise the stability of the phosphorylated Raf-RKIP complex. Notably, PKM2 binds directly and selectively to tyrosine (Tyr, Y)-phosphorylated peptides, and expression of the phosphotyrosine-binding form of PKM2 is required for the rapid growth of cancer cells (1).
1. Kaneko T, Joshi R, Li SS. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal, 10(1), 32. PMID: 23134684

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-a004	SELMODRAFT_134716	D8T929	SELMODRAFT_134716
2		iEKPD-Sem-1893	SELMODRAFT_168086	D8R5K9	SELMODRAFT_168086; SELMODRAFT_179309
3		iEKPD-Sem-1894	SELMODRAFT_271745	D8SP84	SELMODRAFT_271745
4		iEKPD-Sem-1895	SELMODRAFT_451466	D8T7X3	SELMODRAFT_451466