※ PTB family introduction

    The phosphotyrosine-binding (PTB) or phosphotyrosine interaction domain (PID) was originally identified in the protein, Shc, as a domain that could bind tyrosine-phosphorylated growth factor receptors. It was the second domain found to bind phosphotyrosine-containing peptides, having been preceded by the discovery of the Src homology 2 (SH2) domain several years earlier. Proteins with this domain are involved in diverse cellular functions, ranging from receptor signaling to protein targeting (1).

Reference
1. Zeng, L. (2014) Structural insights into FRS2 PTB domain recognition by neurotrophin receptor TrkB. Proteins, 82, 1534-41. PMID: 24470253

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cii-0464	ENSCING00000012307.2	F6UMA7
2		iEKPD-Cii-0468	ENSCING00000019207.1	H2XYD3
3		iEKPD-Cii-0469	ENSCING00000002732.3	F7ALU0
4		iEKPD-Cii-0472	ENSCING00000002393.3	F6QZW7
5		iEKPD-Cii-0470	ENSCING00000020943.1	H2XK86	LOC100177892
6		iEKPD-Cii-0465	ENSCING00000021680.1	H2XVM6	LOC100180686
7		iEKPD-Cii-0471	ENSCING00000007499.3	F6XVX1	LOC100181015
8		iEKPD-Cii-0731	ENSCING00000006400.3	F6PQN7	LOC100181792
9		iEKPD-Cii-0466	ENSCING00000000096.3	F6T5W3	LOC100182079
10		iEKPD-Cii-0467	ENSCING00000023736.1	H2XXC8	LOC104265708
11		iEKPD-Cii-0463	ENSCING00000005057.3	F7A4J9	numb
12		iEKPD-Cii-0732	ENSCING00000008460.3	F6V7W7	tensin