Erinaceus europaeus      pY/SH2


※ SH2 family introduction

    The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adapter proteins that aid in the signal transduction of receptor tyrosine kinase pathways. The yeast genome encodes only one SH2 domain-containing protein, the transcription factor Spt6. Recent study demonstrated that the Spt6 SH2 domain region can binds to Ser-phosphorylated CTD (1).

Reference
1. Kaneko, T. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal, 10, 32. PMID: 23134684


There are 76 genes.  Reviewed (0 or Unreviewed (76

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ere-0659
ENSEEUG00000007972.1
2
iEKPD-Ere-0661
ENSEEUG00000000636.1
3
iEKPD-Ere-0936
ENSEEUG00000009043.1
4
iEKPD-Ere-0950
ENSEEUG00000002945.1
5
iEKPD-Ere-0664
ENSEEUG00000004340.1
6
iEKPD-Ere-0940
ENSEEUG00000009985.1
7
iEKPD-Ere-0675
ENSEEUG00000014532.1
8
iEKPD-Ere-0679
ENSEEUG00000003948.1
9
iEKPD-Ere-0680
ENSEEUG00000000966.1
10
iEKPD-Ere-0681
ENSEEUG00000003791.1
11
iEKPD-Ere-0683
ENSEEUG00000010428.1
12
iEKPD-Ere-0688
ENSEEUG00000001270.1
13
iEKPD-Ere-0691
ENSEEUG00000012242.1
14
iEKPD-Ere-0925
ENSEEUG00000001657.1
A0A1S3A6Y3
ABL1
15
iEKPD-Ere-0946
ENSEEUG00000014995.1
A0A1S3AJS8
ABL2
16
iEKPD-Ere-0938
ENSEEUG00000009758.1
A0A1S2ZCK3
BLK
17
iEKPD-Ere-0671
ENSEEUG00000007293.1
A0A1S3WRS2
BLNK
18
iEKPD-Ere-0931
ENSEEUG00000006072.1
A0A1S3AQA1
BMX
19
iEKPD-Ere-0947
ENSEEUG00000015649.1
A0A1S3ANW5
BTK
20
iEKPD-Ere-0698
ENSEEUG00000009028.1
A0A1S3WC22
CBL
21
iEKPD-Ere-0701
ENSEEUG00000001141.1
A0A1S2ZNR3
CBLB
22
iEKPD-Ere-0674
ENSEEUG00000006940.1
A0A1S3WDY8
CHN1
23
iEKPD-Ere-0668
ENSEEUG00000010877.1
A0A1S3A0B7
CISH
24
iEKPD-Ere-0695
ENSEEUG00000013951.1
A0A1S2ZJV8
CRK
25
iEKPD-Ere-0935
ENSEEUG00000007616.1
A0A1S3AHM6
FES
26
iEKPD-Ere-0924
ENSEEUG00000000884.1
A0A1S2ZL85
FRK
27
iEKPD-Ere-0948
ENSEEUG00000015691.1
A0A1S3A277
FYN
28
iEKPD-Ere-0694
ENSEEUG00000008167.1
A0A1S2ZHA6
GRAP2
29
iEKPD-Ere-0663
ENSEEUG00000014311.1
A0A1S3ARC0
GRB14
30
iEKPD-Ere-0676
ENSEEUG00000001721.1
A0A1S2ZUV4
GRB2
31
iEKPD-Ere-0697
ENSEEUG00000009338.1
A0A1S3WM06
GRB7
32
iEKPD-Ere-0928
ENSEEUG00000004567.1
A0A1S3WBB5
HCK
33
iEKPD-Ere-0667
ENSEEUG00000015743.1
A0A1S3W6M7
INPP5D
34
iEKPD-Ere-0941
ENSEEUG00000011029.1
A0A1S3A3C0
ITK
35
iEKPD-Ere-0949
ENSEEUG00000015940.1
A0A1S3WBK8
LCK
36
iEKPD-Ere-0693
ENSEEUG00000000176.1
A0A1S3WFB7
LOC103116316
37
iEKPD-Ere-0684
ENSEEUG00000003642.1
A0A1S3AH38
LOC103124282
38
iEKPD-Ere-0942
ENSEEUG00000011791.1
A0A1S3AJ87
LOC103124953
39
iEKPD-Ere-0696
ENSEEUG00000015426.1
A0A1S3WVZ4
LOC103127776
40
iEKPD-Ere-0945
ENSEEUG00000014779.1
A0A1S2ZUZ3
MATK
41
iEKPD-Ere-0662
ENSEEUG00000000033.1
A0A1S2ZMZ4
NCK1
42
iEKPD-Ere-0690
ENSEEUG00000008874.1
A0A1S3AAN3
NCK2
43
iEKPD-Ere-0660
ENSEEUG00000002467.1
A0A1S2ZM12
PIK3R3
44
iEKPD-Ere-0959
ENSEEUG00000009326.1
A0A1S2ZB60
PLCG2
45
iEKPD-Ere-0929
ENSEEUG00000004888.1
A0A1S2ZTV3
PTK6
46
iEKPD-Ere-0952
ENSEEUG00000008829.1
A0A1S3A3W4
PTPN11
47
iEKPD-Ere-0658
ENSEEUG00000009239.1
A0A1S2ZH17
RASA1
48
iEKPD-Ere-0665
ENSEEUG00000014519.1
A0A1S3WIZ1
SH2B3
49
iEKPD-Ere-0670
ENSEEUG00000012495.1
A0A1S3AIV3
SH2D2A
50
iEKPD-Ere-0669
ENSEEUG00000012372.1
A0A1S3A3U8
SH2D3C
51
iEKPD-Ere-0673
ENSEEUG00000007463.1
A0A1S2ZQ27
SH2D4A
52
iEKPD-Ere-0971
ENSEEUG00000013016.1
A0A1S3WDI9
SHC2
53
iEKPD-Ere-0968
ENSEEUG00000014866.1
A0A1S3ASN0
SHC3
54
iEKPD-Ere-0970
ENSEEUG00000012551.1
A0A1S2ZCR6
SHC4
55
iEKPD-Ere-0689
ENSEEUG00000002910.1
A0A1S2ZFC0
SLA2
56
iEKPD-Ere-0666
ENSEEUG00000012920.1
A0A1S3W9P8
SLA
57
iEKPD-Ere-0672
ENSEEUG00000007188.1
A0A1S3A0G2
SOCS4
58
iEKPD-Ere-0930
ENSEEUG00000005742.1
A0A1S3W5M3
SRC
59
iEKPD-Ere-0937
ENSEEUG00000009151.1
A0A1S2ZU10
SRMS
60
iEKPD-Ere-0687
ENSEEUG00000002112.1
A0A1S3A721
STAP1
61
iEKPD-Ere-0682
ENSEEUG00000002197.1
A0A1S2ZM30
STAT1
62
iEKPD-Ere-0678
ENSEEUG00000010238.1
A0A1S3ADH8
STAT2
63
iEKPD-Ere-0685
ENSEEUG00000002778.1
A0A1S2ZM23
STAT4
64
iEKPD-Ere-0692
ENSEEUG00000008265.1
A0A1S3A7Y2
SUPT6H
65
iEKPD-Ere-0939
ENSEEUG00000009804.1
A0A1S3AT02
SYK
66
iEKPD-Ere-0934
ENSEEUG00000007089.1
A0A1S3AS48
TEC
67
iEKPD-Ere-0951
ENSEEUG00000007106.1
A0A1S3W987
TNS1
68
iEKPD-Ere-0953
ENSEEUG00000008855.1
A0A1S2ZER0
TNS2
69
iEKPD-Ere-0957
ENSEEUG00000007808.1
A0A1S2ZU72
TNS3
70
iEKPD-Ere-0973
ENSEEUG00000008880.1
A0A1S3A8P3
TNS4
71
iEKPD-Ere-0933
ENSEEUG00000006839.1
A0A1S3ARM5
TXK
72
iEKPD-Ere-0686
ENSEEUG00000010212.1
A0A1S2ZM51
VAV2
73
iEKPD-Ere-0677
ENSEEUG00000004897.1
A0A1S3A2I2
VAV3
74
iEKPD-Ere-0926
ENSEEUG00000001707.1
A0A1S3W8D3
YES1
75
iEKPD-Ere-0699
ENSEEUG00000007444.1
A0A1S3AJL6
ZNF48
76
iEKPD-Ere-0700
ENSEEUG00000006493.1
A0A1S3ARS0
ZSCAN2