Homo sapiens      pY/SH2


※ SH2 family introduction

    The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adapter proteins that aid in the signal transduction of receptor tyrosine kinase pathways. The yeast genome encodes only one SH2 domain-containing protein, the transcription factor Spt6. Recent study demonstrated that the Spt6 SH2 domain region can binds to Ser-phosphorylated CTD (1).

Reference
1. Kaneko, T. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal, 10, 32. PMID: 23134684


There are 112 genes.  Reviewed (111 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Hos-1278
ENSG00000097007.17
P00519
ABL1; ABL; JTK7
2
iEKPD-Hos-1293
ENSG00000143322.19
P42684
ABL2; ABLL; ARG
3
iEKPD-Hos-0934
ENSG00000137936.16
O75815
BCAR3; NSP2; SH2D3B; UNQ271/PRO308
4
iEKPD-Hos-1292
ENSG00000136573.12
P51451
BLK
5
iEKPD-Hos-0939
ENSG00000095585.16
Q8WV28
BLNK; BASH; SLP65
6
iEKPD-Hos-1282
ENSG00000102010.14
P51813
BMX
7
iEKPD-Hos-1271
ENSG00000010671.15
Q06187
BTK; AGMX1; ATK; BPK
8
iEKPD-Hos-1331
ENSG00000110395.6
P22681
CBL; CBL2; RNF55
9
iEKPD-Hos-1332
ENSG00000114423.18
Q13191
CBLB; RNF56; Nbla00127
10
iEKPD-Hos-1333
ENSG00000142273.10
Q9ULV8
CBLC; CBL3; RNF57
11
iEKPD-Hos-0940
ENSG00000128656.13
P15882
CHN1; ARHGAP2; CHN
12
iEKPD-Hos-0945
ENSG00000106069.21
P52757
CHN2; ARHGAP3; BCH
13
iEKPD-Hos-0937
ENSG00000114737.15
Q9NSE2
CISH; G18
14
iEKPD-Hos-0914
ENSG00000109684.14
Q7Z7G1
CLNK; MIST
15
iEKPD-Hos-0900
ENSG00000167193.7
P46108
CRK
16
iEKPD-Hos-0901
ENSG00000099942.12
P46109
CRKL
17
iEKPD-Hos-1283
ENSG00000103653.16
P41240
CSK
18
iEKPD-Hos-0912
ENSG00000070190.12
Q9UN19
DAPP1; BAM32; HSPC066
19
iEKPD-Hos-1296
ENSG00000151422.12
P16591
FER; TYK3
20
iEKPD-Hos-1306
ENSG00000182511.11
P07332
FES; FPS
21
iEKPD-Hos-1269
ENSG00000000938.12
P09769
FGR; SRC2
22
iEKPD-Hos-1287
ENSG00000111816.7
P42685
FRK; PTK5; RAK
23
iEKPD-Hos-1272
ENSG00000010810.17
P06241
FYN
24
iEKPD-Hos-0904
ENSG00000100351.16
O75791
GRAP2; GADS; GRB2L; GRID
25
iEKPD-Hos-0902
ENSG00000154016.13
Q13588
GRAP
26
iEKPD-Hos-0948
ENSG00000189152.10
Q8TC17
GRAPL
27
iEKPD-Hos-0925
ENSG00000106070.17
Q13322
GRB10; GRBIR; KIAA0207
28
iEKPD-Hos-0909
ENSG00000115290.9
Q14449
GRB14
29
iEKPD-Hos-0905
ENSG00000177885.13
P62993
GRB2; ASH
30
iEKPD-Hos-0915
ENSG00000141738.13
Q14451
GRB7
31
iEKPD-Hos-1281
ENSG00000101336.13
P08631
HCK
32
iEKPD-Hos-0918
ENSG00000196684.12
Q96JZ2
HSH2D; ALX
33
iEKPD-Hos-0916
ENSG00000168918.13
Q92835
INPP5D; SHIP; SHIP1
34
iEKPD-Hos-0931
ENSG00000165458.13
O15357
INPPL1; SHIP2
35
iEKPD-Hos-1288
ENSG00000113263.12
Q08881
ITK; EMT; LYK
36
iEKPD-Hos-1298
ENSG00000162434.11
P23458
JAK1; JAK1A; JAK1B
37
iEKPD-Hos-1277
ENSG00000096968.13
O60674
JAK2
38
iEKPD-Hos-1286
ENSG00000105639.18
P52333
JAK3
39
iEKPD-Hos-1307
ENSG00000182866.16
P06239
LCK
40
iEKPD-Hos-0928
ENSG00000043462.11
Q13094
LCP2
41
iEKPD-Hos-1312
ENSG00000254087.7
P07948
LYN; JTK8
42
iEKPD-Hos-1270
ENSG00000007264.14
P42679
MATK; CTK; HYL
43
iEKPD-Hos-0903
ENSG00000158092.6
P16333
NCK1; NCK
44
iEKPD-Hos-0908
ENSG00000071051.13
O43639
NCK2; GRB4
45
iEKPD-Hos-0896
ENSG00000145675.14
P27986
PIK3R1; GRB1
46
iEKPD-Hos-0899
ENSG00000105647.16
O00459
PIK3R2
47
iEKPD-Hos-0897
ENSG00000117461.14
Q92569
PIK3R3
48
iEKPD-Hos-0895
ENSG00000124181.14
P19174
PLCG1; PLC1
49
iEKPD-Hos-1329
ENSG00000197943.9
P16885
PLCG2
50
iEKPD-Hos-1280
ENSG00000101213.6
Q13882
PTK6; BRK
51
iEKPD-Hos-1313
ENSG00000179295.17
Q06124
PTPN11; PTP2C; SHPTP2
52
iEKPD-Hos-1315
ENSG00000111679.16
P29350
PTPN6; HCP; PTP1C
53
iEKPD-Hos-1330
ENSG00000145715.14
P20936
RASA1; GAP; RASA
54
iEKPD-Hos-0950
ENSG00000174791.10
Q13671
RIN1
55
iEKPD-Hos-0951
ENSG00000132669.12
Q8WYP3
RIN2; RASSF4
56
iEKPD-Hos-0954
ENSG00000100599.15
Q8TB24
RIN3
57
iEKPD-Hos-0926
ENSG00000178188.14
Q9NRF2
SH2B1; KIAA1299; SH2B
58
iEKPD-Hos-0932
ENSG00000160999.10
O14492
SH2B2; APS
59
iEKPD-Hos-0927
ENSG00000111252.10
Q9UQQ2
SH2B3; LNK
60
iEKPD-Hos-0933
ENSG00000183918.15
O60880
SH2D1A; DSHP; SAP
61
iEKPD-Hos-0919
ENSG00000198574.5
O14796
SH2D1B; EAT2
62
iEKPD-Hos-0947
ENSG00000027869.11
Q9NP31
SH2D2A; SCAP; TSAD; VRAP
63
iEKPD-Hos-0943
ENSG00000125731.12
Q9BRG2
SH2D3A; NSP1; UNQ175/PRO201
64
iEKPD-Hos-0936
ENSG00000095370.19
Q8N5H7
SH2D3C; NSP3; UNQ272/PRO309/PRO34088
65
iEKPD-Hos-0944
ENSG00000104611.11
Q9H788
SH2D4A; PPP1R38; SH2A
66
iEKPD-Hos-1359
ENSG00000189410.11
Q6ZV89
SH2D5
67
iEKPD-Hos-0959
ENSG00000152292.16
Q7Z4S9
SH2D6
68
iEKPD-Hos-0930
ENSG00000183476.12
A6NKC9
SH2D7
69
iEKPD-Hos-0946
ENSG00000087266.15
P78314
SH3BP2; 3BP2; RES4-23
70
iEKPD-Hos-0913
ENSG00000107338.9
Q15464
SHB
71
iEKPD-Hos-1354
ENSG00000160691.18
P29353
SHC1; SHC; SHCA
72
iEKPD-Hos-1356
ENSG00000129946.10
P98077
SHC2; SCK; SHCB
73
iEKPD-Hos-1355
ENSG00000148082.9
Q92529
SHC3; NSHC; SHCC
74
iEKPD-Hos-1353
ENSG00000185634.11
Q6S5L8
SHC4; SHCD; UNQ6438/PRO21364
75
iEKPD-Hos-0917
ENSG00000105251.10
Q96IW2
SHD
76
iEKPD-Hos-0929
ENSG00000169291.9
Q5VZ18
SHE
77
iEKPD-Hos-0910
ENSG00000138606.19
Q7M4L6
SHF
78
iEKPD-Hos-0906
ENSG00000101082.13
Q9H6Q3
SLA2; C20orf156; SLAP2
79
iEKPD-Hos-0911
ENSG00000155926.13
Q13239
SLA; SLAP; SLAP1
80
iEKPD-Hos-0938
ENSG00000185338.4
O15524
SOCS1; SSI1; TIP3
81
iEKPD-Hos-0923
ENSG00000120833.13
O14508
SOCS2; CIS2; SSI2; STATI2
82
iEKPD-Hos-0942
ENSG00000184557.4
O14543
SOCS3; CIS3; SSI3
83
iEKPD-Hos-0941
ENSG00000180008.8
Q8WXH5
SOCS4; SOCS7
84
iEKPD-Hos-0935
ENSG00000171150.7
O75159
SOCS5; CIS6; CISH5; CISH6; KIAA0671
85
iEKPD-Hos-0924
ENSG00000170677.5
O14544
SOCS6; CIS4; SOCS4
86
iEKPD-Hos-0907
ENSG00000274211.4
O14512
SOCS7; NAP4; SOCS6
87
iEKPD-Hos-1311
ENSG00000197122.11
P12931
SRC; SRC1
88
iEKPD-Hos-1290
ENSG00000125508.3
Q9H3Y6
SRMS; C20orf148
89
iEKPD-Hos-0961
ENSG00000035720.7
Q9ULZ2
STAP1; BRDG1
90
iEKPD-Hos-0957
ENSG00000178078.11
Q9UGK3
STAP2; BKS
91
iEKPD-Hos-0952
ENSG00000115415.18
P42224
STAT1
92
iEKPD-Hos-0949
ENSG00000170581.13
P52630
STAT2
93
iEKPD-Hos-0953
ENSG00000168610.14
P40763
STAT3; APRF
94
iEKPD-Hos-0958
ENSG00000138378.17
Q14765
STAT4
95
iEKPD-Hos-0956
ENSG00000126561.16
P42229
STAT5A; STAT5
96
iEKPD-Hos-0955
ENSG00000173757.9
P51692
STAT5B
97
iEKPD-Hos-0962
ENSG00000166888.11
P42226
STAT6
98
iEKPD-Hos-0960
ENSG00000109111.14
Q7KZ85
SUPT6H; KIAA0162; SPT6H
99
iEKPD-Hos-1300
ENSG00000165025.14
P43405
SYK
100
iEKPD-Hos-1291
ENSG00000135605.12
P42680
TEC; PSCTK4
101
iEKPD-Hos-1320
ENSG00000079308.16
Q9HBL0
TNS1; TNS
102
iEKPD-Hos-1321
ENSG00000111077.17
Q63HR2
TNS2; KIAA1075; TENC1
103
iEKPD-Hos-1319
ENSG00000136205.16
Q68CZ2
TNS3; TEM6; TENS1; TPP
104
iEKPD-Hos-1358
ENSG00000131746.12
Q8IZW8
TNS4; CTEN; PP14434
105
iEKPD-Hos-1275
ENSG00000074966.10
P42681
TXK; PTK4; RLK
106
iEKPD-Hos-1284
ENSG00000105397.13
P29597
TYK2
107
iEKPD-Hos-0920
ENSG00000141968.7
P15498
VAV1; VAV
108
iEKPD-Hos-0921
ENSG00000160293.16
P52735
VAV2
109
iEKPD-Hos-0922
ENSG00000134215.15
Q9UKW4
VAV3
110
iEKPD-Hos-1303
ENSG00000176105.13
P07947
YES1; YES
111
iEKPD-Hos-1289
ENSG00000115085.13
P43403
ZAP70; SRK
112
iEKPD-Hos-0898
ENSG00000278139.1
F6TDL0
LOC110117498-PIK3R3