※ SH2 family introduction

    The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adapter proteins that aid in the signal transduction of receptor tyrosine kinase pathways. The yeast genome encodes only one SH2 domain-containing protein, the transcription factor Spt6. Recent study demonstrated that the Spt6 SH2 domain region can binds to Ser-phosphorylated CTD (1).

Reference
1. Kaneko, T. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal, 10, 32. PMID: 23134684

  Reviewed (4)  or Unreviewed (110) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-1265	ENSSSCG00000004421.4	A1Y2K1	FYN
2		iEKPD-Sus-0928	ENSSSCG00000015631.3	B5KFD7	Grb10
3		iEKPD-Sus-1268	ENSSSCG00000005215.4	O19064	JAK2
4		iEKPD-Sus-0963	ENSSSCG00000000396.3	O02799	STAT2
5		iEKPD-Sus-1303	ENSSSCG00000026816.2	I3LQJ5
6		iEKPD-Sus-0925	ENSSSCG00000023187.3	I3L6D4
7		iEKPD-Sus-1337	ENSSSCG00000027669.3	I3LPY1
8		iEKPD-Sus-0954	ENSSSCG00000028004.2	I3LQT2
9		iEKPD-Sus-0968	ENSSSCG00000031729.1	A0A287A5U2
10		iEKPD-Sus-0971	ENSSSCG00000017897.3	F1RGL4
11		iEKPD-Sus-1269	ENSSSCG00000005706.3	A0A287BB27	ABL1
12		iEKPD-Sus-1288	ENSSSCG00000024674.2	I3LP68	ABL2
13		iEKPD-Sus-0939	ENSSSCG00000006893.3	A0A287BI52	BCAR3
14		iEKPD-Sus-1292	ENSSSCG00000027568.2	I3LPS4	BLK
15		iEKPD-Sus-0944	ENSSSCG00000010504.4	F1SBG3	BLNK
16		iEKPD-Sus-1278	ENSSSCG00000012137.4	K7GKP6	BMX
17		iEKPD-Sus-1289	ENSSSCG00000026742.2	I3LN58	BTK
18		iEKPD-Sus-1315	ENSSSCG00000015115.3	A0A286ZQE1	CBL
19		iEKPD-Sus-1316	ENSSSCG00000022486.2	A0A287AVY5	CBLB
20		iEKPD-Sus-0967	ENSSSCG00000003083.2	F1RMS6	CBLC
21		iEKPD-Sus-0947	ENSSSCG00000022345.2	A0A287APY3	CHN1
22		iEKPD-Sus-0972	ENSSSCG00000032951.1	A0A287AKX8	CHN1
23		iEKPD-Sus-0950	ENSSSCG00000016687.3	A0A287BPP5	CHN2
24		iEKPD-Sus-0943	ENSSSCG00000040581.1	K9IVI9	CISH_tv2; CISH
25		iEKPD-Sus-0924	ENSSSCG00000022448.2	I3LE26	CLNK
26		iEKPD-Sus-0906	ENSSSCG00000033812.1	A0A286ZTD8	CRK
27		iEKPD-Sus-0907	ENSSSCG00000010095.3	F1RKX9	CRKL
28		iEKPD-Sus-1259	ENSSSCG00000001900.3	A0A287BRU6	CSK
29		iEKPD-Sus-0914	ENSSSCG00000039327.1	A0A286ZND2	DAPP1
30		iEKPD-Sus-1291	ENSSSCG00000027074.2	I3LI71	FER
31		iEKPD-Sus-1258	ENSSSCG00000001818.3	F1RMJ0	FES
32		iEKPD-Sus-1260	ENSSSCG00000003578.3	A0A287B9K1	FGR
33		iEKPD-Sus-1266	ENSSSCG00000004434.3	F1RZK6	FRK
34		iEKPD-Sus-0911	ENSSSCG00000000080.3	F1SRA1	GRAP2
35		iEKPD-Sus-0908	ENSSSCG00000018050.3	F1SB17	GRAP
36		iEKPD-Sus-0915	ENSSSCG00000015901.3	A0A287BCB8	GRB14
37		iEKPD-Sus-0910	ENSSSCG00000017206.4	B6E241	GRB2
38		iEKPD-Sus-0921	ENSSSCG00000017495.3	F1RX94	GRB7
39		iEKPD-Sus-1271	ENSSSCG00000007240.3	F1S525	HCK; HCK_tv1
40		iEKPD-Sus-0922	ENSSSCG00000013853.3	F1S9X9	HSH2D
41		iEKPD-Sus-0923	ENSSSCG00000016298.3	A0A287ABR0	INPP5D
42		iEKPD-Sus-0934	ENSSSCG00000014811.3	F1SUW7	INPPL1
43		iEKPD-Sus-1299	ENSSSCG00000038003.1	A0A286ZPK2	ITK
44		iEKPD-Sus-1262	ENSSSCG00000003809.4	K7GME4	JAK1
45		iEKPD-Sus-1281	ENSSSCG00000013888.4	K7GSE8	JAK3
46		iEKPD-Sus-1261	ENSSSCG00000003608.3	A0A287AH06	LCK
47		iEKPD-Sus-0931	ENSSSCG00000017006.3	F1RRX4	LCP2
48		iEKPD-Sus-0904	ENSSSCG00000003909.3	F1S3V4	LOC100511937
49		iEKPD-Sus-1270	ENSSSCG00000006250.3	F1RT53	LYN
50		iEKPD-Sus-1279	ENSSSCG00000013494.3	A0A287BQQ8	MATK
51		iEKPD-Sus-0909	ENSSSCG00000025701.2	A0A287BMS5	NCK1
52		iEKPD-Sus-0913	ENSSSCG00000008144.3	B6E314	NCK2
53		iEKPD-Sus-0903	ENSSSCG00000016958.4	I3LLB7	PIK3R1
54		iEKPD-Sus-0905	ENSSSCG00000013900.3	F1S916	PIK3R2
55		iEKPD-Sus-0902	ENSSSCG00000007356.3	A0A287BD27	PLCG1
56		iEKPD-Sus-1313	ENSSSCG00000002688.3	F1S475	PLCG2
57		iEKPD-Sus-1294	ENSSSCG00000031474.1	A0A286ZYS4	PTK6
58		iEKPD-Sus-1301	ENSSSCG00000030289.2	A0A287AQB6	PTPN11
59		iEKPD-Sus-1304	ENSSSCG00000025537.2	A0A286ZXH2	PTPN6
60		iEKPD-Sus-1314	ENSSSCG00000014146.3	A0A287A3J8	RASA1
61		iEKPD-Sus-0956	ENSSSCG00000012950.2	F1RU47	RIN1
62		iEKPD-Sus-0959	ENSSSCG00000002451.3	A0A287B5Y8	RIN3
63		iEKPD-Sus-0930	ENSSSCG00000007804.3	F1RFI0	SH2B1
64		iEKPD-Sus-0936	ENSSSCG00000007682.4	K7GNP0	SH2B2
65		iEKPD-Sus-0932	ENSSSCG00000009833.4	F1RMZ2	SH2B3
66		iEKPD-Sus-0938	ENSSSCG00000012643.4	F1RU61	SH2D1A
67		iEKPD-Sus-0935	ENSSSCG00000032108.1	A0A286ZJ47	SH2D1B
68		iEKPD-Sus-0941	ENSSSCG00000006466.2	A0A286ZQC3	SH2D2A
69		iEKPD-Sus-0946	ENSSSCG00000022380.2	F1SCM8	SH2D3A
70		iEKPD-Sus-0942	ENSSSCG00000005620.3	F1RS08	SH2D3C
71		iEKPD-Sus-0951	ENSSSCG00000010342.2	F1SEQ5	SH2D4B
72		iEKPD-Sus-1339	ENSSSCG00000003509.3	F1SU08	SH2D5
73		iEKPD-Sus-0953	ENSSSCG00000008240.3	F1SVA8	SH2D6
74		iEKPD-Sus-0937	ENSSSCG00000001764.3	F1RKT6	SH2D7
75		iEKPD-Sus-0952	ENSSSCG00000022004.2	I3LCQ0	SH3BP2
76		iEKPD-Sus-0918	ENSSSCG00000005358.3	F1ST57	SHB
77		iEKPD-Sus-1333	ENSSSCG00000006539.4	F1RGP5	SHC1
78		iEKPD-Sus-1335	ENSSSCG00000040083.1	A0A287BQC2	SHC2
79		iEKPD-Sus-1334	ENSSSCG00000039841.1	A0A287BEY5	SHC3
80		iEKPD-Sus-0916	ENSSSCG00000013503.3	F1S7M3	SHD
81		iEKPD-Sus-0933	ENSSSCG00000006547.3	F1RGM4	SHE
82		iEKPD-Sus-0917	ENSSSCG00000004674.3	F1SN43	SHF
83		iEKPD-Sus-0912	ENSSSCG00000033020.1	A0A287AQ46	SLA2
84		iEKPD-Sus-0920	ENSSSCG00000005949.4	K7GT15	SLA
85		iEKPD-Sus-0945	ENSSSCG00000027855.2	E7CR04	socs1; SOCS1
86		iEKPD-Sus-0948	ENSSSCG00000036956.1	E5EZY0	SOCS3
87		iEKPD-Sus-0949	ENSSSCG00000032332.1	E2IKQ8	socs4; SOCS4
88		iEKPD-Sus-0940	ENSSSCG00000008437.3	E5F1H9	SOCS5
89		iEKPD-Sus-0927	ENSSSCG00000032214.1	C9DRN1	SOCS6
90		iEKPD-Sus-0970	ENSSSCG00000040941.1	A0A287ANR4	SOCS6
91		iEKPD-Sus-0919	ENSSSCG00000018057.3	F6Q553	SOCS7
92		iEKPD-Sus-1272	ENSSSCG00000007334.4	K7GPR7	SRC
93		iEKPD-Sus-1298	ENSSSCG00000036706.1	A0A287AM17	SRMS
94		iEKPD-Sus-0966	ENSSSCG00000008923.3	F1RVF6	STAP1
95		iEKPD-Sus-0960	ENSSSCG00000013506.3	A0A287ASL6	STAP2
96		iEKPD-Sus-0958	ENSSSCG00000016057.3	A0A287BNK4	STAT1
97		iEKPD-Sus-0957	ENSSSCG00000017403.3	A0A2C9F3G4	STAT3
98		iEKPD-Sus-0964	ENSSSCG00000016059.3	E1U8C4	stat4; STAT4
99		iEKPD-Sus-0961	ENSSSCG00000017402.3	A0A0A0MY60	STAT5A
100		iEKPD-Sus-0962	ENSSSCG00000017406.3	E7CR01	stat5B; STAT5B
101		iEKPD-Sus-0969	ENSSSCG00000040435.1	E5F1H4	STAT6
102		iEKPD-Sus-0965	ENSSSCG00000017773.3	A0A287AYH6	SUPT6H
103		iEKPD-Sus-1276	ENSSSCG00000009589.4	A0A286ZZ61	SYK
104		iEKPD-Sus-1275	ENSSSCG00000008820.4	F1SEA4	TEC
105		iEKPD-Sus-1308	ENSSSCG00000000263.3	F1SFS5	TNS2
106		iEKPD-Sus-1307	ENSSSCG00000016725.3	F1ST78	TNS3
107		iEKPD-Sus-1338	ENSSSCG00000017470.3	F1RXE4	TNS4
108		iEKPD-Sus-1274	ENSSSCG00000008819.3	F1SEA6	TXK
109		iEKPD-Sus-0926	ENSSSCG00000013553.2	A0A286ZQX2	VAV1
110		iEKPD-Sus-0929	ENSSSCG00000005743.3	A0A287B8N4	VAV2
111		iEKPD-Sus-1295	ENSSSCG00000031942.1	A0A287BQX1	YES1
112		iEKPD-Sus-1273	ENSSSCG00000008193.4	F1STD6	ZAP70
113		iEKPD-Sus-0955	ENSSSCG00000003741.3	F1SAJ6	ZNF397
114		iEKPD-Sus-0973	ENSSSCG00000011307.3	F1SRB0	ZNF501