※ SH2 family introduction

    The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adapter proteins that aid in the signal transduction of receptor tyrosine kinase pathways. The yeast genome encodes only one SH2 domain-containing protein, the transcription factor Spt6. Recent study demonstrated that the Spt6 SH2 domain region can binds to Ser-phosphorylated CTD (1).

Reference
1. Kaneko, T. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal, 10, 32. PMID: 23134684

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tar-1100	ENSTRUG00000007054.1	H2SY43
2		iEKPD-Tar-1101	ENSTRUG00000002097.1	H2RXF6
3		iEKPD-Tar-1113	ENSTRUG00000003484.1	H2S703
4		iEKPD-Tar-1115	ENSTRUG00000010816.1	H2TRK1
5		iEKPD-Tar-1117	ENSTRUG00000009828.1	H2TJ47
6		iEKPD-Tar-1119	ENSTRUG00000000648.1	H2RN34
7		iEKPD-Tar-1121	ENSTRUG00000007343.1	H2T0E6
8		iEKPD-Tar-1122	ENSTRUG00000005642.1	H2SMJ6
9		iEKPD-Tar-1124	ENSTRUG00000009438.1	H2TGB5
10		iEKPD-Tar-1125	ENSTRUG00000004262.1	H2SCI5
11		iEKPD-Tar-1126	ENSTRUG00000001313.1	H2RSB0
12		iEKPD-Tar-1559	ENSTRUG00000006487.1	H2STZ4
13		iEKPD-Tar-1131	ENSTRUG00000001135.1	H2RR77
14		iEKPD-Tar-1133	ENSTRUG00000016798.1	H2V1E3
15		iEKPD-Tar-1137	ENSTRUG00000006679.1	H2SVH2
16		iEKPD-Tar-1138	ENSTRUG00000007730.1	H2T3H4
17		iEKPD-Tar-1518	ENSTRUG00000004813.1	H2SGG6
18		iEKPD-Tar-1561	ENSTRUG00000009298.1	H2TFD4
19		iEKPD-Tar-1140	ENSTRUG00000008304.1	H2T7Y8
20		iEKPD-Tar-1144	ENSTRUG00000013763.1	H2UDY3
21		iEKPD-Tar-1148	ENSTRUG00000010148.1	H2TLJ2
22		iEKPD-Tar-1562	ENSTRUG00000013214.1	H2U9L8
23		iEKPD-Tar-1149	ENSTRUG00000015557.1	H2US43
24		iEKPD-Tar-1150	ENSTRUG00000009215.1	H2TET3
25		iEKPD-Tar-1152	ENSTRUG00000008255.1	H2T7M0
26		iEKPD-Tar-1153	ENSTRUG00000014382.1	H2UIK0
27		iEKPD-Tar-1525	ENSTRUG00000003632.1	H2S7Y7
28		iEKPD-Tar-1154	ENSTRUG00000005096.1	H2SIJ2
29		iEKPD-Tar-1156	ENSTRUG00000001462.1	H2RT95
30		iEKPD-Tar-1158	ENSTRUG00000005580.1	H2SM06
31		iEKPD-Tar-1164	ENSTRUG00000005438.1	H2SKW8
32		iEKPD-Tar-1536	ENSTRUG00000000517.1	H2RM65
33		iEKPD-Tar-1169	ENSTRUG00000018287.1	H2VC47
34		iEKPD-Tar-1535	ENSTRUG00000012330.1	H2U2R2
35		iEKPD-Tar-1509	ENSTRUG00000014808.1	H2ULL4	abl1
36		iEKPD-Tar-1489	ENSTRUG00000006070.1	H2SQR1	abl2
37		iEKPD-Tar-1491	ENSTRUG00000006468.1	H2STU2	blk
38		iEKPD-Tar-1143	ENSTRUG00000011140.1	H2TTV0	BLNK
39		iEKPD-Tar-1503	ENSTRUG00000012144.1	H2U1C2	btk
40		iEKPD-Tar-1534	ENSTRUG00000015111.1	H2UNS5	cbl
41		iEKPD-Tar-1563	ENSTRUG00000006891.1	H2SWX1	ccr7
42		iEKPD-Tar-1108	ENSTRUG00000011181.1	H2TU60	crk
43		iEKPD-Tar-1107	ENSTRUG00000003912.1	H2SA07	crkl
44		iEKPD-Tar-1514	ENSTRUG00000017074.1	H2V3G1	csk
45		iEKPD-Tar-1496	ENSTRUG00000009120.1	H2TE37	fer
46		iEKPD-Tar-1515	ENSTRUG00000018073.1	H2VAN7	fes
47		iEKPD-Tar-1505	ENSTRUG00000012570.1	H2U4G0	fgr
48		iEKPD-Tar-1490	ENSTRUG00000006360.1	H2SSY6	frk
49		iEKPD-Tar-1483	ENSTRUG00000003538.1	H2S7D1	fyn
50		iEKPD-Tar-1127	ENSTRUG00000000876.1	H2RPN0	GRB14
51		iEKPD-Tar-1110	ENSTRUG00000008254.1	H2T7L8	grb2
52		iEKPD-Tar-1478	ENSTRUG00000001630.1	H2RUE1	hck
53		iEKPD-Tar-1485	ENSTRUG00000004405.1	H2SDI5	itk
54		iEKPD-Tar-1517	ENSTRUG00000018544.1	H2VE41	jak1
55		iEKPD-Tar-1484	ENSTRUG00000004107.1	H2SBF2	jak2
56		iEKPD-Tar-1486	ENSTRUG00000004669.1	H2SFA3	lck
57		iEKPD-Tar-1111	ENSTRUG00000011846.1	H2TZ35	LOC101062391
58		iEKPD-Tar-1102	ENSTRUG00000007584.1	H2T2A6	LOC101062512
59		iEKPD-Tar-1507	ENSTRUG00000014739.1	H2UL58	LOC101063191
60		iEKPD-Tar-1128	ENSTRUG00000009238.1	H2TEY6	LOC101065015
61		iEKPD-Tar-1104	ENSTRUG00000010930.1	H2TSE4	LOC101065244
62		iEKPD-Tar-1168	ENSTRUG00000015703.1	H2UT58	LOC101065277
63		iEKPD-Tar-1487	ENSTRUG00000005980.1	H2SQ58	LOC101065281
64		iEKPD-Tar-1134	ENSTRUG00000012830.1	H2U6B6	LOC101065292
65		iEKPD-Tar-1109	ENSTRUG00000011971.1	H2U037	LOC101065989
66		iEKPD-Tar-1132	ENSTRUG00000007194.1	H2SZ58	LOC101067369
67		iEKPD-Tar-1512	ENSTRUG00000016857.1	H2V1W4	LOC101068778
68		iEKPD-Tar-1157	ENSTRUG00000000102.1	H2RJA9	LOC101068828
69		iEKPD-Tar-1498	ENSTRUG00000009803.1	H2TIZ2	LOC101069639
70		iEKPD-Tar-1136	ENSTRUG00000008894.1	H2TCH3	LOC101069844
71		iEKPD-Tar-1162	ENSTRUG00000015454.1	H2URF8	LOC101071345
72		iEKPD-Tar-1480	ENSTRUG00000002047.1	H2RX32	LOC101072875
73		iEKPD-Tar-1494	ENSTRUG00000008949.1	H2TCV2	LOC101073316
74		iEKPD-Tar-1166	ENSTRUG00000006357.1	H2SSY0	LOC101073409
75		iEKPD-Tar-1116	ENSTRUG00000013116.1	H2U8S8	LOC101075382
76		iEKPD-Tar-1522	ENSTRUG00000006764.1	H2SW24	LOC101076633
77		iEKPD-Tar-1130	ENSTRUG00000012168.1	H2U1H4	LOC101076765
78		iEKPD-Tar-1103	ENSTRUG00000000148.1	H2RJJ2	LOC101077380
79		iEKPD-Tar-1161	ENSTRUG00000011520.1	H2TWM6	LOC101079646
80		iEKPD-Tar-1500	ENSTRUG00000010957.1	H2TSK1	matk
81		iEKPD-Tar-1112	ENSTRUG00000017728.1	H2V8B5	nck1
82		iEKPD-Tar-1114	ENSTRUG00000013538.1	H2UC75	nck2
83		iEKPD-Tar-1105	ENSTRUG00000010476.1	H2TNZ8	pik3r2
84		iEKPD-Tar-1099	ENSTRUG00000011941.1	H2TZW7	pik3r3
85		iEKPD-Tar-1098	ENSTRUG00000000710.1	H2RNJ6	plcg1
86		iEKPD-Tar-1106	ENSTRUG00000007265.1	H2SZS7	plcg2
87		iEKPD-Tar-1521	ENSTRUG00000018529.1	H2VDZ2	ptpn11
88		iEKPD-Tar-1520	ENSTRUG00000006647.1	H2SVA1	ptpn6
89		iEKPD-Tar-1554	ENSTRUG00000001424.1	H2RT08	rasa1
90		iEKPD-Tar-1159	ENSTRUG00000008617.1	H2TAC4	RIN2
91		iEKPD-Tar-1135	ENSTRUG00000008265.1	H2T7N8	SH2B2
92		iEKPD-Tar-1146	ENSTRUG00000007266.1	H2SZT7	sh2d1a
93		iEKPD-Tar-1141	ENSTRUG00000013754.1	H2UDV9	SH2D3A
94		iEKPD-Tar-1167	ENSTRUG00000011361.1	H2TVG6	sh2d5
95		iEKPD-Tar-1560	ENSTRUG00000010389.1	H2TN98	SHC3
96		iEKPD-Tar-1129	ENSTRUG00000016015.1	H2UVG3	shd
97		iEKPD-Tar-1120	ENSTRUG00000010793.1	H2TRD1	sla
98		iEKPD-Tar-1147	ENSTRUG00000010558.1	Q0GRC3	SOCS1; socs1
99		iEKPD-Tar-1142	ENSTRUG00000011640.1	Q2LD51	socs3
100		iEKPD-Tar-1139	ENSTRUG00000015433.1	H2UR85	socs4
101		iEKPD-Tar-1151	ENSTRUG00000012004.1	H2U0C1	socs8
102		iEKPD-Tar-1516	ENSTRUG00000018366.1	H2VCQ9	src
103		iEKPD-Tar-1477	ENSTRUG00000001119.1	H2RR36	SRMS
104		iEKPD-Tar-1165	ENSTRUG00000013090.1	H2U8H0	stat2
105		iEKPD-Tar-1155	ENSTRUG00000015348.1	H2UQK9	stat3
106		iEKPD-Tar-1160	ENSTRUG00000011114.1	H2TTP1	stat4
107		iEKPD-Tar-1163	ENSTRUG00000014399.1	H2UIP1	supt6h
108		iEKPD-Tar-1497	ENSTRUG00000009800.1	H2TIX3	SYK
109		iEKPD-Tar-1527	ENSTRUG00000013916.1	H2UF61	TNS1 (1 of many)
110		iEKPD-Tar-1528	ENSTRUG00000011718.1	H2TY39	tns2
111		iEKPD-Tar-1145	ENSTRUG00000013652.1	H2UD66	VAV1
112		iEKPD-Tar-1118	ENSTRUG00000005204.1	H2SJC1	VAV2
113		iEKPD-Tar-1123	ENSTRUG00000007437.1	H2T159	vav3
114		iEKPD-Tar-1481	ENSTRUG00000003054.1	H2S406	YES1 (1 of many)
115		iEKPD-Tar-1488	ENSTRUG00000006051.1	H2SQL6	zap70