※ NDR family introduction

    The NDR family consists of the mammalian protein kinases NDR1 and NDR2, Drosophila melanogaster NDR, Caenorhabditis elegans SAX1, D. melanogaster and C. elegans large tumor suppressor kinases, Neurospora crassa COT1, Ustilago maydis UKC1, Saccharomyces cerevisiae Cbk1, Dbf2, and Dbf20, Schizosaccharomyces pombe Orb6 and Sid2, and several plant kinases (1). They can be found both in nucleus and cytoplasm. NDR protein kinase participates in MEKK1/2 signaling and acts as the negative regulator (2). Recently study shows that human NDR kinases can control g1/s cell cycle transition by directly regulating p21 stability (3). In addition, NDR protein kinase can be regulated through autophosphorylation and phosphorylation by an upstream kinase under a Ca2+-mediated mechanism (4).

Reference
1. Bichsel, S.J., Tamaskovic, R., Stegert, M.R. and Hemmings, B.A. (2004) Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem, 279, 35228-35235. PMID: 15197186
2. Enomoto, A., Kido, N., Ito, M., Morita, A., Matsumoto, Y., Takamatsu, N., Hosoi, Y. and Miyagawa, K. (2008) Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Oncogene, 27, 1930-1938. PMID: 17906693
3. Cornils, H., Kohler, R.S., Hergovich, A. and Hemmings, B.A. (2011) Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol, 31, 1382-1395 PMID: 21262772
4. Tamaskovic, R., Bichsel, S.J., Rogniaux, H., Stegert, M.R. and Hemmings, B.A. (2003) Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase. J Biol Chem, 278, 6710-6718. PMID: 12493777