Protein Kinase Classification: Atypical/KHK-A※ KHK-A family introduction KHK, known as fructokinase, the first rate-limiting metabolic enzyme, catalyzes the conversion of fructose and ATP to fructose 1-phosphate (F1P) and ADP, respectively. KHK-A can also function as a protein kinase and directly phosphorylate PRPS1 at Thr225 (1).
Reference
1. Lu Z, Hunter T. (2018) Metabolic Kinases Moonlighting as Protein Kinases. Trends Biochem Sci, 43(4), 301-310. PMID: 29463470
Atypical KHK-A in eukaryotes:
1. Lu Z, Hunter T. (2018) Metabolic Kinases Moonlighting as Protein Kinases. Trends Biochem Sci, 43(4), 301-310. PMID: 29463470
Atypical KHK-A in eukaryotes: