Protein Kinase Classification:      CAMK/CAMK2

※ CAMK2 family introduction

    CAMK2 (Calcium/calmodulin-dependent protein kinase type II) belongs to the CAMK group. CAMK2 is a key mediator of Ca2+ signaling. CAMK2 obtains its kinase catalytic activity fowling by binding of Ca2+/Calmodulin on its CAM binding domain. In addition, CAMK2 also undergoes multiple autoregulatory states through phosphorylation of on autoregulatory domain or CAM binding domain. Each phosphorylation state of CAMK2 can regulate related physiological targets (1). Studies show that CAMK2 is involved in sarcoplamic reticulum Ca2+ transport in skeletal muscle and function in dendritic spine and synapse formation and neuronal plasticity (2). CAMK2 also plays an important role in keep de synaptic plasticity which enables LTP and hippocampus-dependent learning (3).

Reference
1. Hudmon, A. and Schulman, H. (2002) Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem J, 364, 593-611. PMID: 11931644
2. Rose, A.J., Kiens, B. and Richter, E.A. (2006) Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol, 574, 889-903 PMID: 16690701
3. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376


CAMK CAMK2 in eukaryotes:

Ailuropoda melanoleuca (4)Anas platyrhynchos (4)Anolis carolinensis (4)
Astyanax mexicanus (7)Bos taurus (4)Caenorhabditis elegans (1)
Callithrix jacchus (5)Canis familiaris (3)Carlito syrichta (4)
Cavia porcellus (4)Cercocebus atys (4)Chlorocebus sabaeus (4)
Choloepus hoffmanni (2)Ciona intestinalis (1)Danio rerio (7)
Dasypus novemcinctus (4)Dipodomys ordii (4)Drosophila melanogaster (1)
Echinops telfairi (4)Equus caballus (4)Erinaceus europaeus (4)
Felis catus (4)Ficedula albicollis (4)Fukomys damarensis (5)
Gadus morhua (4)Gallus gallus (5)Gasterosteus aculeatus (5)
Gorilla gorilla (4)Homo sapiens (4)Ictidomys tridecemlineatus (4)
Latimeria chalumnae (4)Lepisosteus oculatus (4)Loxodonta africana (4)
Macaca fascicularis (4)Macaca mulatta (4)Meleagris gallopavo (4)
Mesocricetus auratus (3)Microcebus murinus (4)Monodelphis domestica (4)
Mustela putorius furo (4)Mus musculus (4)Myotis lucifugus (3)
Nomascus leucogenys (4)Ochotona princeps (4)Octodon degus (4)
Oreochromis niloticus (7)Ornithorhynchus anatinus (5)Oryctolagus cuniculus (4)
Oryzias latipes (7)Otolemur garnettii (4)Ovis aries (4)
Pan paniscus (4)Pan troglodytes (4)Papio anubis (4)
Pelodiscus sinensis (3)Petromyzon marinus (2)Poecilia formosa (8)
Pongo abelii (4)Procavia capensis (4)Pteropus vampyrus (4)
Rattus norvegicus (4)Sarcophilus harrisii (4)Sorex araneus (3)
Sus scrofa (4)Taeniopygia guttata (4)Takifugu rubripes (7)
Tetraodon nigroviridis (9)Tupaia belangeri (4)Tursiops truncatus (4)
Vicugna pacos (2)Xenopus tropicalis (4)Xiphophorus maculatus (7)