※ CASK family introduction

    CASK (Calcium/calmodulin-dependent serine protein kinase) belongs to CAMK group. CASK consists of an N-terminal CaM-kinase domain and a C-terminal set of domains including an L27 domain, an SH3 domain and a C-terminal guanylate kinase domain. The PDZ domain binds to neurexins, syndecans, SynCAMs and putative synaptic cell-adhesion molecules. CASK also interacts with protein Ca2+ channels and K2+ channels. In addition, CASK also acts as a nuclear transcription factor. Studies also show that CASK can interact with CAMK2 and regulate its phosphorylation states (1).

Reference
1. Mukherjee, K., Sharma, M., Urlaub, H., Bourenkov, G.P., Jahn, R., Sudhof, T.C. and Wahl, M.C. (2008) CASK Functions as a Mg2+-independent neurexin kinase. Cell, 133, 328-339. PMID: 18423203