※ DAPK family introduction

    DAPK (Death-associated protein kinase) belongs to the CAMK group. DAPK contains DAPK1, DAPK, Zipper interacting kinase (ZIPK, also named DAPK-3), DAP kinase related apoptosis inducing protein kinase DRAK1 and DRAK2. They share a highly conserved catalytic domain and diverse extracatalytic domains which are associated with different functions. DAPK proteins can activate a variety of downstream cell signaling pathway and then induce cell death via p53 or p53-independent apoptosis or autophagy. In addition, death signal can also stimuli the DAPK cascade signaling pathway and finally induce cell death (1).

Reference
1. Lin, Y., Hupp, T.R. and Stevens, C. (2010) Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J, 277, 48-57. PMID: 19878313