Protein Kinase Classification:      CAMK/PIM

※ PIM family introduction

    PIM consists of three members, PIM-1, PIM-2 and PIM-3. Sequence analysis shows that PIM-1 and PIM-2 share a sequence identity of 61%, whereas PIM-1 and PIM-3 are 77%. PIM kinases play an important role in cancer. PIM-1 and PIM-2 transgenic mice overexpression these genes have been observed to develop lymphomas. In addition, PIM-1 is over expressed in c-myc transgene driven prostate tumors in mice. In human, PIM-1 and PIM-2 are involved in prostate cancer development. Studies show that PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma. The mechanisms that PIMs implicated in cancer have been reported that PIMs act as key regulator in several major proliferative and survival signaling pathways or influence the activity of specific cell cycle molecules and changes in gene expression (1).

Reference
1. Isaac, M., Siu, A. and Jongstra, J. (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat, 14, 203-211. PMID: 21601509


CAMK PIM in eukaryotes:

Ailuropoda melanoleuca (3)Anas platyrhynchos (2)Anolis carolinensis (4)
Astyanax mexicanus (12)Bos taurus (3)Caenorhabditis elegans (2)
Callithrix jacchus (2)Canis familiaris (3)Carlito syrichta (4)
Cavia porcellus (3)Cercocebus atys (3)Chlorocebus sabaeus (3)
Choloepus hoffmanni (2)Ciona intestinalis (3)Ciona savignyi (4)
Danio rerio (344)Dasypus novemcinctus (4)Dipodomys ordii (3)
Echinops telfairi (2)Equus caballus (2)Felis catus (3)
Ficedula albicollis (10)Fukomys damarensis (3)Gadus morhua (4)
Gallus gallus (2)Gasterosteus aculeatus (4)Gorilla gorilla (3)
Homo sapiens (3)Ictidomys tridecemlineatus (3)Latimeria chalumnae (4)
Lepisosteus oculatus (5)Loxodonta africana (3)Macaca fascicularis (3)
Meleagris gallopavo (2)Mesocricetus auratus (3)Microcebus murinus (3)
Monodelphis domestica (3)Mustela putorius furo (2)Mus musculus (3)
Myotis lucifugus (2)Nomascus leucogenys (2)Octodon degus (3)
Oreochromis niloticus (9)Ornithorhynchus anatinus (2)Oryctolagus cuniculus (2)
Oryzias latipes (15)Otolemur garnettii (3)Ovis aries (4)
Pan paniscus (3)Pan troglodytes (3)Papio anubis (3)
Pelodiscus sinensis (2)Poecilia formosa (11)Pongo abelii (2)
Procavia capensis (1)Pteropus vampyrus (3)Rattus norvegicus (3)
Sarcophilus harrisii (3)Sorex araneus (1)Sus scrofa (3)
Taeniopygia guttata (52)Takifugu rubripes (15)Tetraodon nigroviridis (4)
Tupaia belangeri (1)Tursiops truncatus (3)Vicugna pacos (2)
Xenopus tropicalis (2)Xiphophorus maculatus (7)