Protein Kinase Classification: Other/Bud32※ Bud32 family introduction BUD32 belong to "Other" group. One member, PRPK, have been identified in human genome. PRPK is also known as p53-related protein kinase. PRPK was first cloned form interleukin-2-activated cytotoxic T-cell subtraction library, and the expression could also be observed in some human epithelial tumor cell lines, and the testes. PRPK seems to be a homologue of a kinase from yeast, YGR262c, which is a growth-related ser/thr protein kinase. However, the functions of two kinases are not identical. Studies show that PRPK can bind to p53 and mediate the phosphorylation of p53 at ser-15. So PRPK might involve in cell cycle and apoptosis (1).
Reference
1. Abe, Y., Matsumoto, S., Wei, S., Nezu, K., Miyoshi, A., Kito, K., Ueda, N., Shigemoto, K., Hitsumoto, Y., Nikawa, J. et al. (2001) Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. J Biol Chem, 276, 44003-44011. PMID: 11546806
Other Bud32 in eukaryotes:
1. Abe, Y., Matsumoto, S., Wei, S., Nezu, K., Miyoshi, A., Kito, K., Ueda, N., Shigemoto, K., Hitsumoto, Y., Nikawa, J. et al. (2001) Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. J Biol Chem, 276, 44003-44011. PMID: 11546806
Other Bud32 in eukaryotes: