Protein Kinase Classification: Other/TOPK※ TOPK family introduction TOPK (T-LAK cell-originated protein kinase), also known as MAPKK-like protein kinase, are classified into "Other" group (1). One member has been identified in human genome. TOPK was originally found in T-LAK-Cell substraction library, highly expressed in testicular tissue. TOPK plays an important role in spermatogenesis and also expresses in hematologic tumors, including leukemia, lymphoma and myeloma. TOPK can be phosphorylated by cdk1/cyclin B and is unregulated during mitosis. More functions remain to be further understood (2).
Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Matsumoto, S., Abe, Y., Fujibuchi, T., Takeuchi, T., Kito, K., Ueda, N., Shigemoto, K. and Gyo, K. (2004) Characterization of a MAPKK-like protein kinase TOPK. Biochem Biophys Res Commun, 325, 997-1004. PMID: 15541388.
Other TOPK in eukaryotes:
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Matsumoto, S., Abe, Y., Fujibuchi, T., Takeuchi, T., Kito, K., Ueda, N., Shigemoto, K. and Gyo, K. (2004) Characterization of a MAPKK-like protein kinase TOPK. Biochem Biophys Res Commun, 325, 997-1004. PMID: 15541388.
Other TOPK in eukaryotes: