Protein Kinase Classification:      TK/Ack

※ Ack family introduction

    Ack family is non-receptor tyrosine kinases. Two genes encode Ack have been found in human genome, known as TNK1 and Ack1 (TNK2). Sequence analysis of Acks show that Ack family consist of an N-terminal sterile alpha motif (SAM) domain, followed by a kinase catalytic domain and an SH3 domain. Certain Ack contains a Cdc2/Tac-interactive domain (CRIB). Acks are unique NRTKs with SH3 domain located c-terminal to kinase domain. The first member Ack1 was originally cloned from a human hippocampal expression library. Ack1 gene is located on chromosome 3q29 in human, where a region is associated with recurrence of prostate cancer and is a predictor of metastatic relapse in breast cancer.TNK1 was originally cloned from hematopoietic stem/progenitor cells. TNK1 have been reported to block NF-kB activation and promotes apoptosis mediated by TNFα signaling pathway (1).

Reference
1. Prieto-Echague, V. and Miller, W.T. (2011) Regulation of ack-family nonreceptor tyrosine kinases. J Signal Transduct, 2011, 742372. PMID: 21637378


TK Ack in eukaryotes:

Ailuropoda melanoleuca (2)Anas platyrhynchos (1)Anolis carolinensis (1)
Astyanax mexicanus (3)Bos taurus (2)Caenorhabditis elegans (1)
Callithrix jacchus (2)Canis familiaris (2)Carlito syrichta (2)
Cavia porcellus (2)Cercocebus atys (2)Chlorocebus sabaeus (2)
Ciona intestinalis (2)Ciona savignyi (1)Danio rerio (3)
Dasypus novemcinctus (2)Dipodomys ordii (2)Drosophila melanogaster (2)
Echinops telfairi (2)Equus caballus (2)Erinaceus europaeus (1)
Felis catus (2)Ficedula albicollis (1)Fukomys damarensis (2)
Gadus morhua (3)Gallus gallus (1)Gasterosteus aculeatus (3)
Gorilla gorilla (2)Homo sapiens (2)Ictidomys tridecemlineatus (2)
Latimeria chalumnae (2)Lepisosteus oculatus (2)Loxodonta africana (2)
Macaca fascicularis (2)Macaca mulatta (2)Meleagris gallopavo (1)
Mesocricetus auratus (2)Microcebus murinus (1)Monodelphis domestica (1)
Mustela putorius furo (2)Mus musculus (2)Myotis lucifugus (2)
Nomascus leucogenys (2)Ochotona princeps (2)Octodon degus (1)
Oreochromis niloticus (3)Oryctolagus cuniculus (2)Oryzias latipes (3)
Otolemur garnettii (2)Ovis aries (2)Pan paniscus (1)
Pan troglodytes (2)Papio anubis (2)Pelodiscus sinensis (1)
Poecilia formosa (3)Pongo abelii (2)Procavia capensis (2)
Pteropus vampyrus (2)Rattus norvegicus (2)Sarcophilus harrisii (1)
Sorex araneus (1)Sus scrofa (2)Taeniopygia guttata (1)
Takifugu rubripes (3)Tetraodon nigroviridis (3)Tupaia belangeri (2)
Tursiops truncatus (2)Xenopus tropicalis (2)Xiphophorus maculatus (3)