Protein Kinase Classification:      TK/Sev

※ Sev family introduction

    SEV family contains one member in human genome, known as ROS. ROS was first indentified from a chicken genomic DNA library in 1986. Structure analysis shows that ROS consists of an extracellular domain containing a N-linked glycosidation site, a hydrophobic 24-amino acids stretch and a kinase domain. ROS gene is found to be expressed in specific tissues and the size of transcript is diverse according to different tissues, including lungs, kidneys, heart and testis. The expression pattern indicates that ROS is important for the development and mature of organs. In addition, ROS is also involved in cellular growth and differentiation. Furthermore, ROS possess the oncogenic potential and can be displayed after retrovirus transduction.(1)

Reference
1. El-Deeb, I.M., Yoo, K.H. and Lee, S.H. (2010) ROS receptor tyrosine kinase: a new potential target for anticancer drugs. Med Res Rev. PMID: 20687158


TK Sev in eukaryotes:

Ailuropoda melanoleuca (1)Anas platyrhynchos (1)Astyanax mexicanus (1)
Bos taurus (1)Caenorhabditis elegans (1)Callithrix jacchus (1)
Canis familiaris (1)Carlito syrichta (1)Cavia porcellus (1)
Cercocebus atys (1)Chlorocebus sabaeus (1)Choloepus hoffmanni (1)
Danio rerio (1)Dasypus novemcinctus (1)Dipodomys ordii (1)
Drosophila melanogaster (1)Echinops telfairi (1)Equus caballus (1)
Erinaceus europaeus (1)Felis catus (1)Ficedula albicollis (1)
Fukomys damarensis (1)Gallus gallus (1)Gorilla gorilla (1)
Homo sapiens (1)Ictidomys tridecemlineatus (1)Latimeria chalumnae (1)
Lepisosteus oculatus (1)Loxodonta africana (1)Macaca fascicularis (1)
Macaca mulatta (1)Meleagris gallopavo (1)Mesocricetus auratus (1)
Microcebus murinus (1)Monodelphis domestica (1)Mustela putorius furo (1)
Mus musculus (1)Myotis lucifugus (1)Nomascus leucogenys (1)
Ochotona princeps (1)Octodon degus (1)Ornithorhynchus anatinus (1)
Oryctolagus cuniculus (1)Otolemur garnettii (1)Ovis aries (1)
Pan paniscus (1)Pan troglodytes (1)Papio anubis (1)
Pelodiscus sinensis (1)Pongo abelii (1)Procavia capensis (1)
Pteropus vampyrus (1)Rattus norvegicus (1)Sorex araneus (1)
Sus scrofa (1)Taeniopygia guttata (1)Tupaia belangeri (1)
Tursiops truncatus (1)Vicugna pacos (1)