PPBDs-containing Proteins Classification: (pS/pT)/IRF3※ IRF3 family introduction IRFs are interferon regulated transcription factors that are activated by phosphorylation. This domain is structurally related to both MH2 and FHA and it has been proposed that is involved in oligomerization after phosphorylation by binding pSer motifs (1).
Reference
1. http://kinase.com/wiki/index.php/Phospho-Serine/Threonine_binding_domains/
p(S/T) IRF3 in eukaryotes:
1. http://kinase.com/wiki/index.php/Phospho-Serine/Threonine_binding_domains/
p(S/T) IRF3 in eukaryotes:
| Callithrix jacchus (1) | Carlito syrichta (1) | Cercocebus atys (1) |
| Chlorocebus sabaeus (1) | Gorilla gorilla (2) | Homo sapiens (3) |
| Macaca fascicularis (2) | Macaca mulatta (2) | Mesocricetus auratus (1) |
| Mus musculus (2) | Nomascus leucogenys (1) | Otolemur garnettii (1) |
| Pan paniscus (2) | Pan troglodytes (2) | Papio anubis (1) |
| Pongo abelii (3) | Rattus norvegicus (1) |