※ PTB family introduction

    The phosphotyrosine-binding (PTB) or phosphotyrosine interaction domain (PID) was originally identified in the protein, Shc, as a domain that could bind tyrosine-phosphorylated growth factor receptors. It was the second domain found to bind phosphotyrosine-containing peptides, having been preceded by the discovery of the Src homology 2 (SH2) domain several years earlier. Proteins with this domain are involved in diverse cellular functions, ranging from receptor signaling to protein targeting (1).

Reference
1. Zeng, L. (2014) Structural insights into FRS2 PTB domain recognition by neurotrophin receptor TrkB. Proteins, 82, 1534-41. PMID: 24470253