Protein Phosphatase Classification: His-Based PTP/ACP※ ACP family introduction ACPP and ACPT are members of the histidine acid phosphatase family which belongs to the histidine phosphatase superfamily that share a conserved catalytic core centred on a histidine. Mutation of an active site His-12 in ACPP abolished phosphatase activity (1). They have long been known to exhibit tyrosine phosphatase activity and dephosphorylate phosphotyrosine residues in proteins such as ErbB2 or ErbB4 (2).
Reference
1. Zhang XQ, Lee MS, Zelivianski S, Lin MF. (2001) Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem, 276, 2544-50. PMID: 11067847
2. Fleisig H, El-Din El-Husseini A, Vincent SR. (2004) Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Neuroscience, 127, 91-100. PMID: 15219672
His-Based PTP ACP in eukaryotes:
1. Zhang XQ, Lee MS, Zelivianski S, Lin MF. (2001) Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem, 276, 2544-50. PMID: 11067847
2. Fleisig H, El-Din El-Husseini A, Vincent SR. (2004) Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Neuroscience, 127, 91-100. PMID: 15219672
His-Based PTP ACP in eukaryotes: