※ PP1 family introduction

    PP1 enzyme is composed of a catalytic subunit and a regulatory subunit(R subunit). The catalytic domain is conserved among all eukaryotes, and more than 100 regulatory subunits have been found to interact with C domain. Therefore, PP1 is a type of protein phosphatases of functional diversity which regulates a varieties of cellular processes through dephosphorylating different substrates. PP1 can promote the rational use of energy, especially when nutrients are abundant. PP1 plays a key role in the recovery from stress, however promotes apoptosis when cells are damaged beyond repair. In addition, PP1 can regulate the cell cycle (1).

Reference
1. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev, 84, 1-39. PMID: 14715909