※ PP5 family introduction

    PP5 is unique member of PPP family. The most characterized feature is the presence of regulatory domain at N-terminus, TPR domain, which mediates protein-protein interactions. The phosphatase catalytic domain of PP5 is suppressed because PP5 is kept autoinhibited by TPR domain and a C-terminal helix αJ. PP5 can get its catalytic activity only if TPR domain is bound or truncated. PP5 plays an essential role in multiple cellular processes including proliferation, migration, differentiation, electrolyte balance, apoptosis, survival, and DNA damage repair (1).

Reference

1. Hinds, T.D., Jr. and Sanchez, E.R. (2008) Protein phosphatase 5. Int J Biochem Cell Biol, 40, 2358-2362. PMID: 17951098