Protein Phosphatase Classification: PSP-Other/RPAP2※ RPAP2 family introduction RPAP2, also named RNA Pol II-associated protein, can interact with Pol II. Analysis of human RPAP2, S. cerevisiae and S. pombe homolog Rtr1 reveals an evolutionary conserved domain (DUF408) located at N-terminus of the proteins with diverse sequence outside of this region. Studies show that RPAP2 can interact with Rpb1, the largest subunit of Pol II, and mediate the dephosphorylation of Ser7 on CTD of Pol II. The DUF408 domain is involved in establishment of protein-protein interaction (1).
Reference
1. Egloff, S., Zaborowska, J., Laitem, C., Kiss, T. and Murphy, S. (2012) Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes. Mol Cell, 45, 111-122. PMID: 22137580
PSP-Other RPAP2 in eukaryotes:
1. Egloff, S., Zaborowska, J., Laitem, C., Kiss, T. and Murphy, S. (2012) Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes. Mol Cell, 45, 111-122. PMID: 22137580
PSP-Other RPAP2 in eukaryotes: