※ AP family introduction

    Alkaline phosphatases (AP), act as non-specific phosphomonoesterases to hydrolyse phosphate esters, optimally at high pH. Garbers, et al>., show that alkaline phosphatases preferentially dephosphorylate proteins containing phosphotyrosine. The so-called alkaline phosphatases, then, may be a group of membrane-bound glycoproteins that represent a class of phosphoprotein phosphatases that show selectivity for proteins phosphorylated at tyrosine residues (1). In addition, recent studies have demonstrated that ecombinant gIAP can dephosphorylate CD36 at a threonine residue (2).

Reference
1. Swarup G, Cohen S and Garbers DL. (1981) Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases. J Biol Chem, 256, 8197-201. PMID: 6167574
2. Lynes M, Narisawa S, Millán JL and Widmaier EP. (2011) Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet. Am J Physiol Regul Integr Comp Physiol, 301, R1738-47. PMID: 21900644